S-Adenosylmethionine in cell growth, apoptosis and liver cancer
نویسندگان
چکیده
منابع مشابه
S-adenosylmethionine in liver health, injury, and cancer.
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver. Biosynthesis of AdoMet requires the enzyme methionine adenosyltransferase (MAT). In mammals, two genes, MAT1A that is largely expressed by normal liver and MAT2A that is expressed by all extrahepatic tissues, encode MAT. Patients...
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Methionine is an essential amino acid that is metabolized mainly by the liver where it is converted to S-adenosylmethionine (SAMe) by the enzyme methionine adenosyltransferase. Although all mammalian cells synthesize SAMe, the liver is where the bulk of SAMe is generated as it is the organ where about 50% of all dietary methionine is metabolized. SAMe is mainly needed for methylation of a large...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology and Hepatology
سال: 2008
ISSN: 0815-9319,1440-1746
DOI: 10.1111/j.1440-1746.2007.05289.x